019 Colburn Lab
(302) 831-8919
147 Delaware Biotechnology Institute
(302)
831-4687
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M.S. Chemical Engineering, 2002 Rutgers, The State University of New Jersey |
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| B.E. Chemical Engineering, 1999 The Cooper Union for the Advancement of Science and Art |
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Purification of membrane proteins and characterization of protein-detergent complexes
Co-advisor: Prof. Abraham Lenhoff
Roughly one-third of an organism's genes encode for membrane proteins, which serve as drug targets for more than half of all therapeutics on the market today. Several factors limit our understanding of these proteins as well as future research, namely that membrane proteins are generally difficult to express and purify in an active state and are difficult to crystallize. An understanding of the interactions on the molecular level between protein, detergent and other additives will offer increased insight into the ability of surfactants to stabilize membrane proteins in the form of protein-detergent complexes and aid in our ability to select conditions suitable to protein crystallization.